CD3 epsilon Antibody (rC3e/6967) [Janelia Fluor® 585] Summary
| Additional Information | Recombinant Monoclonal Antibody |
| Immunogen | Recombinant fragment (around aa1-200) of human CD3 epsilon protein (exact sequence is proprietary) |
| Localization | Cell surface. Cytoplasm. |
| Marker | T-Cell Marker |
| Specificity | Recognizes the epsilon-chain of CD3, which consists of five different polypeptide chains (designated as gamma, delta, epsilon, zeta, and eta) with MW ranging from 16-28kDa. |
| Isotype | IgG1 Kappa |
| Clonality | Monoclonal |
| Host | Mouse |
| Gene | CD3E |
| Purity | Protein A or G purified |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward |
Applications/Dilutions
| Dilutions |
|
| Application Notes | Optimal dilution of this antibody should be experimentally determined. |
Packaging, Storage & Formulations
| Storage | Store at 4C in the dark. |
| Buffer | 50mM Sodium Borate |
| Preservative | 0.05% Sodium Azide |
| Purity | Protein A or G purified |
Notes
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
Alternate Names for CD3 epsilon Antibody (rC3e/6967) [Janelia Fluor® 585]
- CD3 epsilon
- CD3e antigen
- CD3e antigen, epsilon polypeptide (TiT3 complex)
- CD3e molecule, epsilon (CD3-TCR complex)
- CD3e
- CD3-epsilon
- FLJ18683
- T3E
- T-cell antigen receptor complex, epsilon subunit of T3
- T-cell surface antigen T3/Leu-4 epsilon chain
- T-cell surface glycoprotein CD3 epsilon chain
- TCRE
Background
CD3 epsilon is a subunit of CD3. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits: CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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